Process for preparing (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran-

Details Process for preparing (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran- Process for preparing (1R,2R)-2-(3-pyridyl)-tetrahydrothiopyran-

1990-10-31

1992-06-09

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40904

Patent

active

051208520

ABSTRACT:
Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: ##STR1## (R.sub.1 =alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxides of formulae: ##STR2## employed alone or mixed, the (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides thereby obtained and pharmaceutical compositions containing them.
(1R,2R)-2-(3-Pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides are especially useful as antihypertensives.

REFERENCES:
patent: 3395142 (1968-07-01), Clemens
Morrison et al. Organic Chemistry p. 367, pp. 371-383.

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