Polycyclic ethyl alkylamide melatonergic agents

Details Polycyclic ethyl alkylamide melatonergic agents Polycyclic ethyl alkylamide melatonergic agents

1998-03-04

1999-09-07

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514450, 514452, 514453, 514468, 549348, 549354, 549358, 549383, 549432, 549468, A61K 3134, A61K 31335, C07D30777, C07D31770

Patent

active

059488174

ABSTRACT:
Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH.sub.2).sub.n, wherein n is 1-4;

REFERENCES:
patent: 5736578 (1998-04-01), Watson et al.
J. Arendt, et al., "Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial", British Med. J., 292, p. 1170, (May 3, 1986).
V. M. Cassone, et al., "Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin", J. of Biological Rhythms, 1 (3), pp. 219-229 (1986).
S. M. Reppert, et al., "Molecular characterization of a second melatonin receptor expressed in human retina and brain: The Mel.sub.1b melatonin receptor", Proc. Natl. Acad. Sci., USA, 92, pp. 8734-8738, (Sep. 1995).
S. M. Reppert, et al., "Cloning and Characterization of a Mammalian Melatonin Receptor that Mediates Reproductive and Circadian Responses", Neuron, 13, pp. 1177-1185, (Nov. 1994).

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