Method for improving morbidity and/or mortality

Details Method for improving morbidity and/or mortality Method for improving morbidity and/or mortality

1997-03-12

1999-09-07

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142225, 5142238, 514247, 514249, 514255, 514258, 514349, 514869, A61K 3855

Patent

active

059487992

ABSTRACT:
This invention relates to a method for reducing morbidity and/or mortality in a mammal with congestive heart failure due to non-ischemic etiology comprising administering amlodipine or a pharmaceutically acceptable amlodipine acid addition salt, and, optionally, a diuretic and/or digoxin. The invention further relates to methods for treating patients with congestive heart failure due to non-ischemic etiology, comprising administering a non-ischemic congestive heart failure treating amount of amlodipine or a pharmaceutically acceptable amlodipine salt and, optionally, a diuretic and/or digoxin. The invention also provides a kit which comprises a container means and a) amlodipine and a diuretic, b) amlodipine and digoxin, or c) amlodipine, digoxin and a diuretic; and a kit which comprises a container means and a) amlodipine, an angiotensin converting enzyme (ACE) inhibitor and a diuretic, b) amlodipine, an ACE inhibitor and digoxin, or c) amlodipine, an ACE inhibitor, digoxin and a diuretic. Further, this invention relates to compositions comprising amlodipine or a pharmaceutically acceptable salt thereof and one or both of digoxin and/or a diuretic.

REFERENCES:
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Packer, M. et al., Supplement to Journal of the American College of Cardiology, vol. 17, No. 2, Supplement A, 274A, Mar. 6, 1991, 2:30 p.m.
Cohn, J. N., Drugs, vol. 47, Supplement 4, 1994, pp. 47-58.
Elkayam, U. et al., Supplement to Journal of the American College of Cardiology, vol. 22, No. 4, Oct. 1993: 139A-144A.
Singh, S. et al., The New England Journal of Medicine, vol. 333, No. 2, Jul. 13, 1995, pp. 77-82.
Packer, M. et al., The New England Journal of Medicine, vol. 335, No. 15, Oct. 10, 1996, pp. 1107-1114.
CIBIS Investigators and Committees, The Cardiac Insufficiency Bisoprolol Study (CIBIS), Circulation vol. 90, No. 4, Oct. 1994, pp. 1765-1773.

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