Chemoprevention of electrophilic damage by mercaptopurine analog

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3141

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051207532

ABSTRACT:
Analogs of 6-mercaptopurine have been found to enhance the detoxification of various electrophilic toxicants in vivo, while having minimal cytotoxicity themselves. This property allows such compounds to act as scavengers for electrophilic toxicants, thereby preventing the cellular damage caused by such toxic agents.

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The U.S. governmentr may own certain rights in this invention pursuant to NIEHS grant No ES03602.

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