Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-29
1999-09-07
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514275, 544330, 544331, 544332, 544316, A61K 31505, C07D40514, C07D23902, C07D40100
Patent
active
059487860
ABSTRACT:
A compound of formula (1) ##STR1## wherein X.sup.1 is amino or hydroxyl, X.sup.2 is carbonyl and the like R.sup.1 is an alkyl, an aryl and the like, R.sup.2 is hydrogen and the like, and R.sup.3 is an alkyl and the like, or a pharmaceutical acceptable salt thereof is effective for inibiting the production and/or secretion of tumor necrosis factor in a patient in need of such inhibition.
REFERENCES:
patent: 5763448 (1998-06-01), Carling et al.
Chem. Pharm. Bull., "Synthesis of Piperidine Derivatives with a Quinazoline Ring System as Potential Antihypertensive Agents", vol. 34 (1986), Haruki Takai et al.
Fujita Hitoshi
Fujiwara Norio
Hirota Fumiyo
Kawakami Hajime
Murata Shinobu
Kifle Bruck
Shah Mukund J.
Sumitomo Pharmaceuticals Company Limited
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