Suppressory agents against hypercoagulation

Details Suppressory agents against hypercoagulation Suppressory agents against hypercoagulation

1998-08-11

1999-09-07

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, A61K 3857

Patent

active

059487526

ABSTRACT:
According to the present invention, there are provided suppressory agents against hypercoagulation which comprise as an effective ingredient protein C inhibitor with a molecular weight of 54 to 57 kDa (DS-PAGE) being capable of suppressing function of the blood coagulation system.

REFERENCES:
Suzuki, Protein C Inhibitor Methods In Enzymology, vol. 222, pp. 385-399, 1993.
Marlar et al., "Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation", Blood, vol. 66, No. 1, 1985, pp. 59-63.
Ecke et al., "Inhibition of the tissue kallikrein by protein C inhibitor", The Journal of Biological Chemistry, vol. 267, No. 10, 1992, pp. 7048-7052.
Rezaie, et al., "Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex", The Journal of Biological Chemistry, vol. 270, No. 43, pp. 25336-25339 (1995).

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