Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-10
1999-09-07
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 697, 4352523, 4353201, 435325, 530350, 536 231, 536 234, 536 235, C12P 2100, C07H 2104, C07K 1446
Patent
active
059486392
ABSTRACT:
The invention provides isolated nucleic acids molecules, designated EMI1 nucleic acid molecules, which encode proteins involved in growth factor, e.g., TGF-.beta., cell signaling. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing EMI1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an EMI1 gene has been introduced or disrupted. The invention still further provides isolated EMI1 proteins, fusion proteins, antigenic peptides and anti-EMI1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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Falb Dean A.
Gimeno Carlos J.
Kemmerer Elizabeth
Mandragouras Amy E.
Millennium Pharmaceuticals Inc.
Romeo David
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