Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-05-14
1999-09-07
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 235, 536 241, 536 2433, 536 2431, C12Q 168, C12P 1934, C07H 2104
Patent
active
059486163
ABSTRACT:
A method is provided for identifying a human subject as having an increased or decreased risk of developing essential hypertension, comprising determining the presence in the subject of an allele in the promoter region of the subject's tissue kallikrein gene correlated with an increased or decreased risk of developing essential hypertension, the presence of the allele identifying the subject as having an increased or decreased risk of developing essential hypertension.
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Richards et al. "Human Glandular Kallikrein Genes: Genetic and Physical Mapping of the KLK1 Locus Using a Highly Polymorphic Microsatellite PCR Marker" Genomics 11:77-82, 1991.
Pravenec et al. "Cosegregration of Blood Pressure with a Kallikrein Gene Family Polymorphism" Hypertension 17(2):242-246, Feb. 1991.
Woodley-Miller et al. "Restriction Fragment Length Polymorphisms Mapped in Spontaneously Hypertensive Rats Using Kallikrein Probes" J. Hypertension 7(11):865-871, 1989.
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Evans et al. "Structure and Chromosomal Localization of the Human Renal Kallikrein Gene" Biochemistry 27(9):3124-3129, 1988.
Chao Julie
Chao Lee
MUSC Foundation for Research Development
Myers Carla J.
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