Potent inducers of terminal differentiation and method of use th

Details Potent inducers of terminal differentiation and method of use th Potent inducers of terminal differentiation and method of use th

1994-05-19

1997-12-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514532, 514544, 514551, 514563, 514615, 514616, 560 8, 560115, 560159, 560160, 562450, 562455, 564156, 564157, 564158, 544277, 546187, 546189, 546262, 548192, 548193, H01N 4390, H01N 4342, C07C23300, C07D27704

Patent

active

057008116

ABSTRACT:
This invention is directed to compounds having the structure: ##STR1## wherein R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine or thiazoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, and n is an integer from about 4 to about 8. This invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. The invention further provides pharmaceutical compositions comprising a therapeutically effective amount of the compounds of the present invention and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 2279560 (1942-04-01), Dietrich
patent: 2279973 (1942-04-01), Dietrich
patent: 2346665 (1944-04-01), Cupery
patent: 2895991 (1959-06-01), Randall et al.
patent: 3450673 (1969-06-01), McKillip
patent: 3632783 (1972-01-01), Stonis
patent: 3875301 (1975-04-01), Windheuser
patent: 4056524 (1977-11-01), Walker et al.
patent: 4442305 (1984-04-01), Weitl et al.
patent: 4480125 (1984-10-01), Haas et al.
patent: 4537781 (1985-08-01), Darling et al.
patent: 4611053 (1986-09-01), Sasa
patent: 4614815 (1986-09-01), Cognigni et al.
patent: 4801748 (1989-01-01), Murahashi et al.
patent: 4863967 (1989-09-01), Hall et al.
patent: 4882346 (1989-11-01), Driscoll et al.
patent: 5055608 (1991-10-01), Marks et al.
patent: 5175191 (1992-12-01), Marks et al.
patent: 5330744 (1994-07-01), Pontremoli et al.
Chemical Abstract vol. 98, No. 19/1329, Tabernero et al, (1981), "Antitrypanosomal (T. venezuelense) and antimycotic effect of various hydroxamic acids".
Marks et al., Proc. Natl. Acad. Sci., vol. 86, pp. 6358-6362 (Aug. 1989).
Chun et al., Cancer Treatment Reports, vol. 70, pp. 991-996 (Aug. 1986).
Reuben et al., J. Biolog. Chem., vol. 253, pp. 4214-4218 (Jun. 1978).
Tanaka et al., Proc. Natl. Acad. Sci. (USA), vol. 72, pp. 1003-1006 (Mar. 1975).
Fibach et al., Cancer Research, vol. 37, pp. 440-444 (Feb. 1977).
Melloni et al., Chem. Abs., vol. 109, No. 47737e (1988).
Hozumi et al., Int. J. Cancer, vol. 23, pp. 119-122 (1979).
Haces et al., J. Med. Chem., vol. 30, pp. 405-409 (1987).
Das et al., Chem.Abs., vol. 101, No. 54665t (1984).
Brown et al., Chem. Abs., vol. 105, No. 78501v (1986).
Hynes, J. Med. Chem., vol. 13, No. 6, pp. 1235-1237 (1971).
Tabernero et al., Chem. Abs., vol. 98, No. 191329v (1983).
Morrison and Boyd, Organic Chemistry (3rd ed. Allyn and Bacon Boston) (1973) p. 755.
Weitl et al., J. Org. Chem., vol. 46, pp. 5234-5237 (1981).

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