Propylene-bridged bidentate silanes

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428406, 556406, 556465, B32B 516

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active

059485310

ABSTRACT:
The present invention provides propylene-bridged bidentate silane reagents for modifying the surface of liquid chromatography supports, these supports and methods of making and using the same. When bonded to the surface of a support material, the resulting modified support material provides improved properties, such as better separations and more stable support materials, especially when used in liquid chromatography. These bidentate silanes have the general structure: RSiMe(NMe.sub.2)--(CH.sub.2).sub.3 --SiMeR--NMe.sub.2. R is an n-octadecyl group or an n-tetradecyl group, and Me is a methyl group. When reacted with a silica surface, the resulting modified surface has a structure: silica.

REFERENCES:
patent: 3505785 (1970-04-01), Kirkland
patent: 3722181 (1973-03-01), Kirkland et al.
patent: 3782075 (1974-01-01), Kirkland
patent: 3795313 (1974-03-01), Kirkland et al.
patent: 3979546 (1976-09-01), Lewis
patent: 4010042 (1977-03-01), Boyer
patent: 4010242 (1977-03-01), Iler et al.
patent: 4131542 (1978-12-01), Bergna et al.
patent: 4504549 (1985-03-01), Pines et al.
patent: 4600646 (1986-07-01), Stout
patent: 4666717 (1987-05-01), Smith et al.
patent: 4699717 (1987-10-01), Riesner et al.
patent: 4746572 (1988-05-01), Glaich et al.
patent: 4874518 (1989-10-01), Kirkland et al.
patent: 5108595 (1992-04-01), Kirkland et al.
Jones et al., Characterization and Evaluation of Cyanopropyl Polysiloxane Stationary Phases for Gas Chromatography, 1984, vol. 298, pp. 389-397, Journal of Chromatography.
Lork et al., Role of the Functional Group in n-Octyldimethylsilances in the Synthesis of C.sub.8 Reversed:Phase Silica Packings for High Performance Liquid Chromatography, (1986), vol. 352, pp. 199-211, Journal of Chromatography.
Boksanvi et al., Reaction of n-Alkylkimethylsilanols and n-Oxaalkyldimethylsilanols with the Hydrated Surface of Silicon Dioxide--The Question of the Limiting Surface Concentration, (1976), vol. 6, pp 95-137, Advances in Colloid and Interface Science.
Sindorf et al., Solid-State NMR Studies of the Reactions of Silica Surfaces with Polyfunctional Chloromethylsilanes and Ethoxymethylsilanes, 1983, vol. 105, pp. 3767-3776, J. Am. Chem. Soc.
Welsch et al., Characterization of a New Dehydroxylated Reversed-Phase Material, 1983, vol. 267 pp. 39-48, Journal of Chromatography
1985, vol. 103, p. 668, 71494v, Chemical Abstracts.
R.K. Iler "The Chemistry of Silica," pp. 97-98, John Wiley, NY, NY (1979).
Kirkland et al., Synthesis and Characterization of Highly Stable Bonded Phases for High-Performance Liquid Chromatography Column Packings, 1988, vol. 61, pp. 2-11, J. Am. Chem. Soc.
Kirkland et al., Stability of Silica-Based, Endcapped Columns with pH 7 and 11 Mobile Phases for Reversed-Phase High-Performance Liquid Chromatography, 1997, vol. A762, pp. 97-112, Journal of Chromatography.
Kirkland et al., High pH Mobile Phase Effects on Silica-Based Reversed-Phase High-Performance Liquid Chromatographic Columns, 1995, vol. A691, pp. 3-19, Journal of Chromatograhy.
Claessens et al., Effect of Buffers on Silica-Based Column Stability in Reversed-Phase High-Performance Liquid Chromatography, 1996, vol. A728, pp. 259-270, Journal of Chromatography.
Smith et al., The Efficient Analysis of Neutral and Highly Polar Pharmaceutical Compounds Using Reversed-Phase and Ion-Exchange Electrochromatography, 1995, pp. 197-203, Chromatographia vol. 41, No. 3/4.
L. R. Snyder and J.J. Kirkland, "An Introduction to Modern Liquid Chromatograph," Chapter 7, John Wiley, NY, NY (1979).
J. J. Kirkland et al., Bidentate Silane Statonary Phases for Reversed-Phase High-Performance Liquid Chromotography, Analytical Chem., vol. 70, No. 20, pp. 4344-4352, Oct. 15, 1998.

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