Derivatives of para-guanidino-L-phenylalanine and methods of pre

Details Derivatives of para-guanidino-L-phenylalanine and methods of pre Derivatives of para-guanidino-L-phenylalanine and methods of pre

1975-09-05

1978-10-03

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

424 94, 1951035R, 562430, 562439, C07C14940, C12K 104

Patent

active

041185757

ABSTRACT:
The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine.
The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.

REFERENCES:
patent: 3622615 (1971-11-01), Nicolaides et al.
patent: 3852338 (1971-10-01), Kaiser et al.
Fieser, Experiments in Org. Chemistry, D.C. Heath and Co., Boston, 3rd Ed. Rev. (1955), pp. 90-91.
Jameson et al., Biochem. J. (1973), 131, 107-117.
Hickinbottom, Reactions of Organic Compounds, Longmans, Green & Co., New York (1950), 100.
Weygand, Organic Preparations, Interscience Publishers Inc., New York (1945), 174.

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