Process for the preparation of pyrryl-2-acetonitrile

Details Process for the preparation of pyrryl-2-acetonitrile Process for the preparation of pyrryl-2-acetonitrile

1979-02-02

1983-02-15

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D207337

Patent

active

043742564

ABSTRACT:
Pyrryl-2-acetonitriles corresponding to the formula ##STR1## in which R.sub.1 stands for hydrogen or an alkyl group having 1-4 carbon atoms prepared from dialkyl-(pyrryl-2-methyl)-amine corresponding to the formula ##STR2## in which R.sub.1 is defined as above and R.sub.2 and R.sub.3 stand for alkyl groups having 1-4 carbon atoms, are alkylated with alkyl halides such as methyl chloride or methyl bromide to form the corresponding trialkyl-(pyrryl-2-methyl)-ammonium chloride quaternary salts and then reacted with an aqueous solution of alkali cyanide in the presence of a water-immiscible solvent under conditions which provide more economical utilization of reactants and process equipment.

REFERENCES:
patent: 3523952 (1970-08-01), Orth et al.
patent: 3882146 (1975-05-01), Wiegand
Whitmore; Org. Chem., vol. 1, pp. 72-82, 165, 166, 167, (1951).
Carson et al.; J. Org. Chem., vol. 42, pp. 1096-1097, (1977).

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