Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide hav

Details Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide hav Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide hav

1985-03-28

1987-05-12

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 3116

Patent

active

046650989

ABSTRACT:
A dosage of N-(4-hydroxyphenyl)retinamide, also known as fenretimide, of the following formula: ##STR1## with increased bioavailability comprising corn oil and a non-ionic surfactant. The formulation if useful in the treatment of breast or bladder cancer, psoriasis and acne.

REFERENCES:
patent: 4190594 (1980-02-01), Gander et al.
patent: 4323581 (1982-04-01), Gander
"Pharmacokinetics of N-(4-Hydroxyphenyl)-all-trans-Retinamide in Rats", Brian N. Swanson et al., Laboratory of Chemoprevention, National Cancer Institute, vol. 8, No. 3, (1979), pp. 168-172.
"N-(4-Hydroxyphenyl)retinamide, A New Retinoid for Prevention of Breast Cancer in Rat", Richard C. Moon et al., IIT Research Institute, Chicago, IL, vol. 39, (1979), pp. 1339-1346.
"Biopharmaceutics of Drugs Administered in Lipid-Containing Dosage Forms I; GI Absorption of Griseofulvin from an Oil-in-Water Emulsion in the Rat", Philip J. Carrigan et al., Journal of Pharmaceutical Sciences, vol. 62, No. 9, (1973), pp. 1476-1479.
"The Theory and Practice of Industrial Pharmacy", Leon Lachman et al., Lea & Febiger, Philadelphia, (1970), pp. 359-384.
"Effect of Lipid Vehicles on the Oral Absorption of a Model Compound (DDT)", K. Palin et al., J. Pharm. Pharmacol., (1980), vol. 32, Supplement p. 62P.
"Hypotensive Action of Commercial Intravenous Amiodarone and Polysorbate 80 in Dogs", William B. Gough et al., Journal of Cardiovascular Pharmacology, vol. 4, p. 375, (1982).
"Communications, `Effect of Formulation on the Bioavailability of Retinol, D-.alpha.-Tocopherol and Riboflavine` ", N. E. Bateman et al., J. Pharm. Pharmacol., (1984), vol. 36, pp. 461-464.

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