Method for minimizing disturbances in circadian rhythms of bodil

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3140

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046650865

ABSTRACT:
Alleviating the effects of disturbances in circadian rhythms using melatonin.

REFERENCES:
Letter to the Editor-"Can Melatonin Alleviate Jet Lag?" appearing at p. 426 of The British Medical Journal of Aug. 6, 1983, and submitted by J. Arendt and V. Marks.
Arendt, et al., (1977), "Radioimmunassay of Melatonin: Human Serum and Cerebrospinal Fluid".
Hoffman, K. (1981), "The Role of the Pineal Gland in the Photoperiodic Control of Seasonal Cycles in Hamsters" in Biological Clocks in Seasonal Reproductive Cycles, ed. B. K. Follet & D. E. Follett, pp. 237-251.
Herbert, J. (1981), "The Pineal Gland and Photoperiodic Control of the Ferret's Reproductive Cycle" in Biological Clocks in Seasonal Reproductive Cycles, ed. B. K. Follet & D. E. Follet, pp. 261-276.
Reiter, R. J. (1980), "The Pineal and its Hormones in the Control of Reproduction in Mammals", Endocr. Rev. 1, 109-131.
Symons, A. M., Arendt, J. & Lund, C. A. (1983), "Melatonin Feeding Decreases Prolactin Levels in the Ewe", J. Endocr. 99, 41-46.
Arendt, J. and Marks, V., "Physiological Changes Underlying Jet Lag", British Medical Journal, Jan. 16, 1982, pp. 144-146.
Redman, J. Armstrong, S., and Ng, K. T., "Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin", Science, vol. 219, pp. 1089-1091; Mar. 4, 1983.
Cramer, H., et al., "On the Effects of Melatonin on Sleep and Behavior in Man", Advances in Biochemical Psychopharmacology, vol. 11, pp. 187-191, 1974.
Carman, J. S., et al., "Negative Effects of Melatonin on Depression", Am. J. Psychiatry, 133:10, pp. 1181-1186, Oct. 1976.
Vollrath, L., et al., "Sleep Induction by Intranasal Application of Melatonin", Advances in Bioscience, 29, pp. 327-329, 1981.
Nordlund, J. J., and Lerner, A. B., "The Effects of Oral Melatonin on Skin Color and on the Release of Pituitary Hormones", JCE & M, vol. 45, No. 4, pp. 768-774, 1977.
Anton-Tay, F., et al., "On the Effect of Melatonin Upon Human Brain, its Possible Therapeutic Implications", Life Sciences, vol. 10, Part I, pp. 841-850, 1971.
Arendt, J. (1983), "Biological Rhythms", Internat. Med. 3, 6-9, Aug., 1983.
Fevre-Montange, et al., J. Clin. Endocrinol. Metab. 52 642-649 (1981).
Akerstedt et al., Biological Psychiatry 17 547-554 (1982).
Cramer et al., 1st. Europ. Congr. Sleep Res. Based 1972, pp. 488-491.
Reinhard et al., 2nd Europe. Congr. Sleep Res., Rome 1974, pp. 510-522.
Pavel et al., Adv. Biosciences 29 343-374 (1981).

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