Cyclic alkylidenyl N-(lower-alkyl)-3-(pyridinyl)anilinomethylene

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2603435, 542423, 260297R, 2603406, C07D40512, C07D31906

Patent

active

041185579

ABSTRACT:
Cyclic alkylidenyl N-(lower-alkyl)-3-PY-anilinomethylenemalonates (I), where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting cyclic alkylidenyl (lower-alkoxy)methylenemalonate (II) with N-(lower-alkyl)-3-PY-aniline (III). Also, I is heated with polyphosphoric acid to produce 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-PY-3-quinolinecarboxylic acid, known antibacterial agents. The N-(lower-alkyl)-3-PY-anilines are produced by reducing the corresponding N-(3-PY-phenyl)-(lower-alkanamides).

REFERENCES:
patent: 3563981 (1971-02-01), Lesher et al.

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