Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1992-01-08
1994-11-01
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351721, 4352523, 43525411, 4353201, 536 235, C12N 500, C12N 1500, C12N 120, C12N 116
Patent
active
053607350
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a human 5-HT.sub.1F receptor, an isolated protein which is a human 5-HT.sub.1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT.sub.1F receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT.sub.1F receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT.sub.1F receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT.sub.1F receptor, pharmaceutical compounds related to human 5-HT.sub.1F receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT.sub.1F receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT.sub.1F receptor.
REFERENCES:
patent: 5155218 (1992-10-01), Weinshank et al.
Schwab, E. F. et al. Soc. Neurosci. Abstr., 15(1): 546, 1989, Abstract 222.9.
Weisberg et al., Drug Development Research, 26(3): 225-234, 1992.
Leonhardt, S. et al., J. Neurochem., 53(2): 465-71, 1989.
Branchek Theresa
Hartig Paul R.
Weinshank Richard L.
Allen Marianne Porta
Hill Jr. Robert J.
Synaptic Pharmaceutical Corporation
White John P.
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