Antigen for trachoma lymphogranuloma venereum (LGV) and non-gono

Details Antigen for trachoma lymphogranuloma venereum (LGV) and non-gono Antigen for trachoma lymphogranuloma venereum (LGV) and non-gono

1976-04-27

1978-10-03

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 260112R, 424 12, G01N 3316, A61K 4300

Patent

active

041184696

ABSTRACT:
Solubilized antigens of C. trachomatis strain LGV-434 upon analysis using two-dimensional immunoelectrophoresis yielded a single antigen which was found to be consistently precipitated by sera of patients with C. trachomatis infections. This antigen as antigen-antibody complex was employed as an immunogen to prepare a rabbit monospecific antiserum to this component or antigen. This monospecific antiserum demonstrated the presence of the antigen in each of the 15 strains of C. trachomatis organisms and was non-reactive with strains of C. psittaci. The C. trachomatis specific antigen was purified by immunoadsorption chromatography using monospecific antiserum as a specific ligand covalently bound to agarose gel columns and the resulting purified antigen employed to detect antibody from the sera of lymphogranuloma venereum patients using counterimmunoelectrophoresis. When the C. trachomatis specific antigen is isotopically labeled and utilized in the highly sensitive radioimmune assay antibody to the antigen should be demonstrated and a serological test based thereon should be applicable for the serological diagnosis of non-gonococcal urethritis (NGU).

REFERENCES:
patent: 2355676 (1944-08-01), Rake et al.
patent: 2415234 (1947-02-01), Bunney et al.
patent: 3646346 (1972-02-01), Catt
Collins et al., Chemical Abstracts, vol. 72, No. 11, Mar. 16, 1970, p. 216, abstract No. 53182d.
Haider et al., Chemical Abstracts, vol. 74, No. 3, Jan. 18, 1971, p. 175, abstract No. 11472j.
Chemical Trade Names and Commercial Synonyms, Haynes, Van Nostrand Co., Inc., NY, 1955, p. 428.

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