Process for the preparation of cyclic hexapeptide

Details Process for the preparation of cyclic hexapeptide Process for the preparation of cyclic hexapeptide

1981-07-15

1983-02-15

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125S, C07C10352

Patent

active

043740600

ABSTRACT:
There is disclosed a process for preparing a cyclic hexapeptide somatostatin analog, specifically cyclo (D-Trp-Lys-Val-Phe-N-Me-Ala-Tyr). The cyclic hexapeptide is synthesized in large quantities in a solution synthesis procedure. However, because of the unexpectedly rapid cyclization rate of this compound, conditions have been developed such that a much more concentrated solution, and thus smaller volumes of the reaction medium, may be employed than would be expected.

REFERENCES:
patent: 4102877 (1978-07-01), Nutt
patent: 4108987 (1978-08-01), Veber et al.
patent: 4285857 (1981-08-01), Chipens et al.
European Published Patent Specification Appln. No. 80303826.4, Publication NO. 0029310-Mar. 5, 1980.
Chem. Abstr., vol. 66, (1967), 22714a.
Chem. Abstr., vol. 83, (1975), 205804a.
Chem. Abstr., vol. 74, (1971), 12350e.
Chem. Abstr., vol. 73, (1970), 66888j.

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