Chemotactic peptide pharmaceutical applications

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 111, 424 165, A61K 5100, A61M 3614

Patent

active

057004447

ABSTRACT:
High affinity chemotactic peptides containing a biological-function domain which includes at least two linked N-formyl-Met-Leu-Phe sequences and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in a variety of diseases and pathologic conditions, and particularly for diagnosis and treatment of infections, inflammations and other diseases and conditions.

REFERENCES:
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4732864 (1988-03-01), Tolman
patent: 4877868 (1989-10-01), Reno et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5091514 (1992-02-01), Fritzberg et al.
patent: 5102990 (1992-04-01), Rhodes
patent: 5128119 (1992-07-01), Griffiths
patent: 5162505 (1992-11-01), Dean et al.
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5371184 (1994-12-01), Rajagopalan et al.
patent: 5443816 (1995-08-01), Zamora et al.
Fischman, A.J., et al., "Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptide Analogs," J. Nuclear Medicine, vol. 32, No. 3, pp. 483-491 (1991).
Fischman, A.J., et al., Abstract, "Imaging of Focal Sites of Inflammation in Non-Human Primates with a TC99m-Labeled Chemotactic Peptide," Proc. of 40th Ann. Meeting, Journal of Nuclear Medicine, Abstract No. 415 (1992).
Vallabhaiosula, S., et al., "Evaluation of Technetium-99m Labeled Peptides for Imaging Infection in a Rabbit Model," Proc of 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract No. 414 (1993).
Babich, J.W., et al., "Technetium-99m-Labeled Chemotactic Peptides for Infection Imaging: Comparison with Indium-111-labeled Leukocytes in Infected Rabbits," Proc. 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract 833 (1993).
Babich, J.W., et al., "Tc99m-Labeled Hydrazino Nicotinamide Derivatized Chemotactic Peptide Analogs for Imaging Focl Sites of Bacterial Infection in Rabbits," Proc. 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract 836 (1993).
Kraus, J, et al., "Cyclic Tetrameric Clusters of Chemotactic Peptides as Superactive Activators of Lysozyme, Release from Human Meutrophils," BioChem. and BioPhy. Res. Comm., vol. 124, No. 3 pp. 939-944 (1994).
Ravel, P., "Polymeric Analogues of N-formyl Peptides are Potent Activators of Degranulation and Superoxide Production by Human Neutrophils," Biochem. and Biophys. Res. Comm., vol. 171, No. 1, pp. 266-272 (1980).
Cox, et al., "Technetium Labelled Somatostatin a Potential Agent for in Vivo Tumour Localization," 7th Intn'l Sympos. on Radiopharmacology, Abstract, p. 16 (1991).
Fischman, Alan J., "A Ticket to Ride: Peptide Radiopharmaceuticals," J. Nucl. Med., vol. 34, No. 12 pp. 2253-2263, (Dec. 1993).
Knaw, B.A., et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibregen," J. of Nucl. Med., Basic Sciences, vol. 23, No. 11, pp. 1011-1019 (1982).
Kondo, M., et al., "Studies of Dimeric fMLF with High Chemotactic Activities," Peptides--Chemistry and Biology, Proc. of 12th Amer. Peptide Symp., Cambridge MA (Jun. 16-21, 1991).
Pimm, M.V., et al., "In labelling of a branched polypeptide drug carrier with a poly(L-lysine) backbone," Int'l J. Pharm., Vo. 79 (1992), pp. 77-80 .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemotactic peptide pharmaceutical applications does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemotactic peptide pharmaceutical applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemotactic peptide pharmaceutical applications will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1800213

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.