Phosphatidyl inositol analogs useful as anti-inflammatory/analge

Details Phosphatidyl inositol analogs useful as anti-inflammatory/analge Phosphatidyl inositol analogs useful as anti-inflammatory/analge

1982-03-30

1985-05-07

Waltz, Thomas A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260349, 260455P, 260928, 260940, 260941, 260944, 260948, 260949, 260953, 260954, C07F 910, C07F 908, C07F 9113, A61K 3166

Patent

active

045157227

ABSTRACT:
Phosphatidyl inositol analogs are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These phosphatidyl inositol analogs are prepared by condensation of a protected inositol with a substituted phosphonic or phosphorous acid followed by removal of protecting groups.

REFERENCES:
patent: 3632627 (1972-01-01), Gordon et al.
patent: 3704254 (1972-11-01), Aneja
patent: 4129650 (1978-12-01), Betzing et al.
Engel, Chem. Review, 77, (3), p. 349 (1977).
V. A. Sukhanou et al., Zh. Obs. Khim. (Eng. translation), 47, 2130 (1977).
R. Sundler et al., J. Biol. Chem., 253, 4175 (1978).
P. D. Wightman, Biochem. J. 197, 523 (1981).

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