Synthesis of interphenylene prostaglandin analogs

Details Synthesis of interphenylene prostaglandin analogs Synthesis of interphenylene prostaglandin analogs

1985-09-23

1987-04-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 63, 544 65, 544235, 548124, 548126, 548217, 548241, 548262, 548369, 548453, 549 15, 549 32, 549350, 549363, 549426, 549427, 549435, 549463, 560 51, 560 53, 560 57, 560101, 562462, 562466, 562491, 568633, 568659, 568660, 568808, C07D30700, C07C 6730

Patent

active

046580336

ABSTRACT:
New interphenylene prostaglandin (PGH) analogs are prepared by a method which involves reacting a bicyclic olefin, an acetylene compound and a benzylic halide together, in the presence of a palladium(O) catalyst in a single-step synthesis. By this technique a large number of new interphenylene PGH analogs can be prepared, which are useful as inhibitors of arachidonic acid induced platelet aggregation.

REFERENCES:
patent: 4020097 (1977-04-01), Nelson
patent: 4084058 (1978-04-01), Nelson
patent: 4113755 (1978-09-01), Larock
patent: 4349689 (1982-09-01), Aristoff
patent: 4351949 (1982-09-01), Larock
patent: 4420632 (1983-12-01), Aristoff
patent: 4436934 (1984-03-01), Larock
patent: 4463015 (1984-07-01), Haslanger et al.
patent: 4474804 (1984-10-01), Das et al.
patent: 4522949 (1985-07-01), Das et al.
Catellani et al., Tetrahedron Letters, 23 (43), pp. 4517-4520, (1982).
Maitlis, The Org. Chem. of Palladium, vol. 1, Academic Press, p. 72 (1971).
Larock et al, Tetrahedron Letters, 23 (10), pp. 1071-1074 (1982).

Affiliated with

Also associated with

Rating

Synthesis of interphenylene prostaglandin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of interphenylene prostaglandin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of interphenylene prostaglandin analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1786989