Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1986-04-16
1987-04-14
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530315, 514807, C07K 706, C07K 716
Patent
active
046580158
ABSTRACT:
Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
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Callahan James F.
Huffman William F.
Moore Michael L.
Yim Nelson C.
Edgerton William H.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
Suter Stuart R.
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