Process for the synthesis of benzo[b]thiophenes

Details Process for the synthesis of benzo[b]thiophenes Process for the synthesis of benzo[b]thiophenes

1995-06-07

1996-10-29

Dees, Jos e G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 54, 549 55, 549 56, C07D33364, C07D33366, C07D33362

Patent

active

055697720

ABSTRACT:
The present invention is directed to a new process for the synthesis of 2-aryl benzo[b]thiophenes, and to novel intermediates therefor.

REFERENCES:
patent: 4380635 (1983-04-01), Peters
patent: 5512701 (1996-04-01), Hoard et al.
patent: 5514826 (1996-05-01), Hoard et al.
Campaigne and Cline, "A New Synthesis of Thiophenes and Condensed Thiophenes by Ring Closure of Disulfides", J. Org. Chem., 21, 39-44 (1956).
Campaigne, "Thiophenes and their Benzo Derivatives: (III) Synthesis and Applications", in Comprehensive Heterocyclic Chemistry, vol. 4, Part 3, 863-894 (1984).
Ando, "Prolysis of Styryl Sulphoxides and Sulphides. Formation of Benzothiophen Derivatives via Intramolecular Cyclization of Thiyl Radicals", J. Chem. Soc., Chem. Comm., 704-5 (1975).
Shelton and Davis, "t-Butylsulfenic Acid", J. Am. Chem. Soc., 89(3), 718-19 (1967).
Mazzanti et al., "Intramolecular Trapping Reactions of Vinylsulfenic Acid Tautomers of Enethiolisable Sulfines", J. Chem. Soc., Perkin. Trans. I, 3299-3304 (1994).
Mukaiyama and Saigo, "A Convenient Method for the Preparation of Vinyl Sulfides from Carbonyl Compounds by Using TiCl.sub.4 ", Chem Letters, 479-482 (1973).
Kodama et al., "Attractive Interaction between Aliphatic and Aromatic Systems", Tetrahedron Letters, 2105-08 (1977).
Casey and Manage, "Stereoselective Conjugate Additions of Benzyl Sulphoxides to .alpha.,.beta.-Unsaturated Esters", Tetrahedron Letters, 30(49), 6919-22 (1989).
Casey et al., "Stereoselective Conjugate Additions of Sulphoxide Stabilised Carbanions to .alpha.,.beta.-Unsaturated Esters", Tetrahedron Letters, 29(45), 5821-24 (1988).
Davis et al., "Chemistry of Sulfenic Acids. 1. Synthesis of Trimethylsilyl Arenesulfenates (Arenesulfenic Acids)", J. Org. Chem., 45, 1650-53 (1980).
Davis and Friedman, "Trimethylsilyl 2-Nitrobensenesulfenate (2-Nitrobenzensulfenic Acid)", J. Org. Chem., 41(5), 897-898 (1976).
Barton and Zika, "Adducts of Acetylenes and Sulfur Dichloride", J. Org. Chem., 35, 1729-33 (1970).
Guindon et al., "Direct Synthesis of Thioethers from Thiols and Alcohols", J. Org. Chem., 48, 1357-59 (1983).
Pyne and Boche, "Stereoselective Reactions of Lithium and Zinc tert-Butyl Phenylmethyl Sulfoxide with Carbonyl Compounds and Imines", J. Org. Chem., 54, 2663-67 (1989).

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