Peptide-Chelator conjugates

Details Peptide-Chelator conjugates Peptide-Chelator conjugates

1994-02-25

1996-10-29

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530329, 530330, A61K 3800, C07K 500, C07K 700

Patent

active

055697453

ABSTRACT:
Peptide-chelator conjugates are provided that when labelled with a traceable metal are useful for diagnostic imaging of sites of inflammation. The peptide component is an antagonist of the naturally occurring tetrapeptide tuftsin while the chelator component serves as a labelling site for metals, in particular radionuclide metals such as technetium-99m.

REFERENCES:
patent: 5433816 (1995-08-01), Zamora et al.
patent: 5480970 (1996-01-01), Pollak et al.
Beherucci et al., Agents Actions, Special Conf. Issue (1992) C115-C117.
Siemion et al., Int. J. Peptide Prot. Res. 35 (1990) pp. 428-433.
Bump et al., "Isolation And Subunit Composition Of Tuftsin Receptor", Proc. Natl. Acad. Sci., U.S.A., 1986, vol. 83, No. 19, pp. 7187-7191.
Najjar et al., "The Chemistry And Biology of Tuftsin.sup.1 ", Lymphokin Reportsd, vol., pp. 157-179.
Konopinska et al., "Elongated Tuftsin Analogues-Synthesis And Biological Investigation", pp. 35-43, vol. 419 Database Cancerlit, Abstract No. 384993.
Florentin et al., "Immunopharmacological Properties Of Tuftsin And Of Some Analogues", pp. 177-191, Database Embase, Elsevier Science Publishers, Abstract No. 5599439.

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