Mitotic inhibitors preventing posterior lens capsule opacificati

Details Mitotic inhibitors preventing posterior lens capsule opacificati Mitotic inhibitors preventing posterior lens capsule opacificati

1985-03-06

1987-04-14

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514912, A61K 3119

Patent

active

046579303

ABSTRACT:
Disclosed are mitotic inhibitors effective for and methods of preventing posterior lens capsule opacification after extracapsular extraction. The mitotic inhibitors comprise osmotically balanced solutions containing either methotrexate or retinoic acid, or both, in at least the minimal effective dosage at the end of one lens epithelial cell cycle. The mitotic inhibitors are instilled in the anterior chamber of the eye preferably immediately after the lens has been removed.

REFERENCES:
patent: 3089823 (1963-05-01), Czarnecki
Dispersa--Therapeutic Index--re: Vitamin A.
ARVO-1984-Invest. Ophth. & Vis. Sci. 25 (3)(1984)--Ubels et al.--Vitamin A is Present as Retinol in Tears.
Chem. Abst. 99:47928t (1983)--Chan et al.
Chem. Abst. 99:47929n (1983)--Baylor College of Med.

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