Antimicrobial and antitumor phenazine carboxaldehydes and deriva

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544347, 435886, C07D24146, C07D40112, C07D40312, A61K 31495

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active

046579095

ABSTRACT:
Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.
A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

REFERENCES:
patent: 3359165 (1967-12-01), Bergy
Tipton et al, J.A.C.S., 92, 1425-6 (1970).
Bergy, Chem. Abs., 71, 53512r (1969).
Tipton, Chem. Abs., 76, 126940u (1972).

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