Diuretic peptide, and production and use thereof

Details Diuretic peptide, and production and use thereof Diuretic peptide, and production and use thereof

1985-02-27

1987-04-14

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3724, C07K 710

Patent

active

046578919

ABSTRACT:
There are disclosed a new peptide .beta.-rANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing the .beta.-rANP or an acid addition salt thereof; and processes for the production thereof.

REFERENCES:
patent: 4496544 (1985-01-01), Needleman
patent: 4508712 (1985-04-01), Needleman
Febs 1268, vol. 167, No. 2, (1984) 352-357.
Jamieson, J. D. and Palade, G. E., "Specific Granules in Atrial Muscle Cells", The Journal of Cell Biology, vol. 23 (1964) pp. 151-172.
de Bold, A. J. et al, "A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats", Life Sciences, vol. 28 (1981) pp. 89-94.
Keeler, R., "Atrial Natrieuretic Factor has a Direct, Prosteglan-Independent Action on Kidneys", Can. J. Physiol. Pharmacol., vol. 60 (1982) pp. 1078-1082.
Currie, M. G. et al, "Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria", Science, vol. 221 (1983) pp. 71-73.
Flynn, T. G. et al, "The Amino Acid Sequence of an Atrial Peptide with Potent Diuretic and Natriuretic Properties", Biochemical and Biophysical Research . . . .
Kangawa, K. and Matsuo, H., "Purification and Complete Amino Acid Sequence of .alpha.-Human Atrial Natriuretic Polypeptide (.alpha.-haNP)", Biochemical and Biophysical . . . .

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