Process for P-nitrobenzyl ester cleavage in cephalosporin

Details Process for P-nitrobenzyl ester cleavage in cephalosporin Process for P-nitrobenzyl ester cleavage in cephalosporin

1995-05-30

1996-07-16

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540219, C07D50104

Patent

active

055368301

ABSTRACT:
A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30.degree.-50.degree. C.

REFERENCES:
patent: 3781282 (1973-12-01), Garbrecht
patent: 3799924 (1974-03-01), Jackson
patent: 3925372 (1975-12-01), Chauvette
"Chemistry of Cephalosporin Antibiotics. XXIX 3-Halo- and 3-Methoxy-3-cephems", Journal of the American Chemical Society, 96:15, Jul. 24, 1974, pp. 4986-4987.

Affiliated with

Also associated with

Rating

Process for P-nitrobenzyl ester cleavage in cephalosporin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for P-nitrobenzyl ester cleavage in cephalosporin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for P-nitrobenzyl ester cleavage in cephalosporin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1785422