Process for preparing 4-bromomethyl-3-methoxy-benzoic esters

Details Process for preparing 4-bromomethyl-3-methoxy-benzoic esters Process for preparing 4-bromomethyl-3-methoxy-benzoic esters

1996-08-26

1998-02-17

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6976

Patent

active

057193096

ABSTRACT:
A process for preparing 4-bromomethyl-3-methoxybenzoic esters of the formula ##STR1## entails the corresponding 4-methyl-3-methoxybenzoic esters being reacted in chlorobenzene or an ester as solvent with N-bromosuccinimide with exposure to light of wavelength 10.sup.-5 to 10.sup.-8 m at -10.degree. to 120.degree. C.

REFERENCES:
Angew. Chemie Int. Ed., Bd. 19, Nr. 6, 1980, pp. 464-465; W. Offermann; F. Vogtle: "Brominations with N-Bromosuccinimide: Solvent and Selectivity".
Chem. Ber., Bd. 114, 1981, pp. 1048-1064, K. Bockmann, F. Vogtle: "Intraanular phenyl-substituierte Phane--Synthese und dynamische Stereochemie".
J. Med. Chem., Bd. 33, 1990, pp. 1771-1781, F.J. Brown et al.: "Evolution of a Series of Peptidoleukotriene Antagonists".

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