Superoxide radical inhibitor

Details Superoxide radical inhibitor Superoxide radical inhibitor

1997-03-25

2000-06-27

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, A61K 31425

Patent

active

060807644

ABSTRACT:
A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), ##STR1## [wherein R.sup.1 represents a phenyl group which may have 1-3 lower alkoxy groups as substituent(s) on the phenyl ring, a phenyl group having a lower alkylenedioxy group, or the like; R.sup.2 represents a hydrogen atom, a phenyl group, a halogen atom, a lower alkoxycarbonyl group, a lower alkyl group, an amino-lower alkyl group which may have a lower alkyl group as a substituent, a dihydrocarbostyril group, or the like; R.sup.3 represents a group of the formula, ##STR2## (R.sup.4B represents a hydroxyl group, a carboxy group, a lower alkenyl group or a lower alkyl group. m represents 0, 1 or 2); X represents a sulfur atom or an oxygen atom] or a salt thereof.

REFERENCES:
patent: 1970656 (1934-08-01), Johnson
patent: 3244703 (1966-04-01), Yates et al.
patent: 3320270 (1967-05-01), Grogan et al.
patent: 3462448 (1969-08-01), Kelyman
patent: 3470195 (1969-09-01), O'Mant
patent: 3579529 (1971-05-01), Brown et al.
patent: 3625999 (1971-12-01), Tramier et al.
patent: 3821237 (1974-06-01), Malen et al.
patent: 3862169 (1975-01-01), Weberndoerfer
patent: 3869468 (1975-03-01), Tarzia
patent: 4001420 (1977-01-01), Malen et al.
patent: 4072689 (1978-02-01), Tarzia
patent: 4206117 (1980-06-01), Von Philipsborn et al.
patent: 4259341 (1981-03-01), Baldwin et al.
patent: 4282364 (1981-08-01), Amato et al.
patent: 4329459 (1982-05-01), McCall et al.
patent: 4535089 (1985-08-01), Matsumoto et al.
patent: 4602027 (1986-07-01), Meguro et al.
patent: 4791200 (1988-12-01), Press et al.
patent: 4966855 (1990-10-01), Deneke et al.
Synthesis of 2,5-Disubstituted Thiazoles and Their Reactions With Grignard Reagents, Subhi S. Al-Azawe, J. Iraqi. Chem. Soc., vol. 13 No. 1, pp. 1-13, 1988.
Decision making in drug research, 1983, pp. 173-188, "Symbiotic Approach to Drug Design," B.J.R. Nicolaus.
"Synthesis and Cardiotonic Activity of 5-(2-Substituted Thiazol-4-YL)-2-Pyridones and Thiazolo [4,5-f]Quinolinones", Fukatsu et al., Heterocycles, vol. 29, No. 8, pp. 1517-1528, 1989.
"Heterocycles from 2-bromoacetyl heterocycles", Kempter et al., Chemical Abstracts, vol. 70, 11630b, 1969.
J. Med. Chem., 1988, vol. 31, pp. 1778-1785 (1984).
Chemical Abstracts, vol. 101, (1), 101: 7145p.
Chemical Abstracts, vol. 100, (9), 100: 68214m (1984).
Chemical Abstracts, vol. 106, (15), 106: 116059n (1987).
Chemical Abstracts, vol. 91, (23), 91: 186442c (1987).
Chemical Abstracts, vol. 90, (13), 90: 103886f (1979.
Chemical Abstracts, vol. 87, (19), 87:152066Zk (1977).
Chemical Abstracts, vol. 89, (17), 89: 146824f (1978).
Chemical Abstracts, vol. 96, (9), 96: 68881a (1982).
Chemical Abstracts, vol. 86, (23), 86:171308m (1977).
Chemical Abstracts, vol. 86, (17), 86:121232m (1977).
Chemical Abstracts, vol. 82, (9), 57594u (1975).
Chemical Abstracts, vol. 87, (7), 87: 53142a (1977).
Chemical Abstracts, vol. 87, (13), 87: 96735p (1977).
Chemical Abstracts, vol. 87, (13), 87: 96736q (1977).
Chemical Abstracts, vol. 85, (25), 85:192613b (1976).
Chemical Abstracts, vol. 87, (3), 87:16437e (1977).
Chemical Abstracts, vol. 87, (9), 87:68218d (1977).
Chemical Abstracts, vol. 85, (21), 85:159962e (1976).
Chemical Abstracts, vol. 84, (13), 90050c (1976).
Chemical Abstracts, vol. 69, (11), 43837v (1968).
Chemical Abstracts, vol. 60, (3), (29219) (1964).
Chemical Abstracts, vol. 96, (15), 96:122757e (1982).
Chemical Abstracts, vol. 96, (15), 96:122675b (1982).
Chemical Abstracts, vol. 92, (13), 92:110908j (1980).
Chemical Abstracts, vol. 81, (15), 91408a (1974).
Chemical Abstracts, vol. 85, (25), 85:192614c (1976).
Chemical Abstracts, vol. 88, (25), 88:190657q (1978).
Chemical Abstracts, vol. 94, (3), 94: 15628a (1981).
Chemical Abstracts, vol. 103, (3), 103: 22508u (1985).
Chemical Abstracts, vol. 104, (9), 104: 68782c (1986).
Chemical Abstracts, vol. 73, (15), 77117h (1970).
Chemical Abstracts, vol. 75, (21), 129708q (1971).
Chemical Abstracts, vol. 89, (17), 89:197388z (1978).
Chemical Abstracts, vol. 109, (3), 109:22883m (1988).
Chemical Abstracts, vol. 66, (22), 96203e (1967).
Chemical Abstracts, vol. 86, (9), 86:55326 (1977).
Chemical Abstracts, vol. 96, (3), 96:20015u (1982).

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