Colon specific gene and protein

Details Colon specific gene and protein Colon specific gene and protein

Filed on

1998-09-29

Date issued

2000-06-27

Examiner

Prouty, Rebecca E.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Peptide containing doai

Other Related Categories

435 691, 4353201, 4352523, 536 231, 536 235, 530350, A61K 3800, C07K 100, C12P 2106, C12N 120, C12N 1500

Type

Patent

Status

active

Patent number

060807229

Description

ABSTRACT:
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5380645 (1995-01-01), Vogelstein
patent: 5837841 (1998-11-01), Bandman et al.
Singh et al., Carcinogenesis, 15(7):1317-1323 (1994).
Ueda et al., Gastroenterology, 104(4):911-917 (1993).
O'Connell, Cancer Supplement, 70(6):1732-1739 (1992).
Mount et al., Cancer Research, 54(23):6160-6166 (1994).
The New England Biolabs Catalog 1993-94 Edition, pp. 92-95.
Nicolaides et al., Nature, 371:75-80 (1994).
Geneseq Database, W37866, W37929, Aug. 21, 1998.

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