Triazolyl-phenoxyacetic acid compounds which have useful pharmac

Details Triazolyl-phenoxyacetic acid compounds which have useful pharmac Triazolyl-phenoxyacetic acid compounds which have useful pharmac

1994-08-19

1996-07-16

Northington Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548255, C07D24904, A61K 3141

Patent

active

055367364

ABSTRACT:
We proposed a novel compound having an activity of PGI.sub.2 receptor agonist.
A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R.sup.1).dbd.N.about.OR.sup.2, --CH(R)NH--OR.sup.2, --COE, --SO.sub.2 E, --CH.sub.2 --NR.sup.3 --Y, --Z--NR.sup.3 --CONR.sup.4 R.sup.5, --CH.sub.2 --OR.sup.6, --CO.sub.2 R.sup.6, --CH.sub.2 --O.about.N.dbd.CR.sup.7 R.sup.8, --CH.sub.2 --O--NHCHR.sup.7 R.sup.8, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl;

REFERENCES:
Biagi et al, IL. Farmaco, vol. 43 (7-8) 1988, pp. 597-611.
Biagi et al, IL Farmaco, vol. 41(8), 1986, pp. 597-610.
Chemical Abstracts, vol. 114, Abstract No. 185, 397y, 1991, p.781.

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