Substituted benzoylguanidines, their use as a medicament or diag

Details Substituted benzoylguanidines, their use as a medicament or diag Substituted benzoylguanidines, their use as a medicament or diag

1996-07-03

1998-02-17

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514400, 514407, 514427, 546332, 5483361, 5483751, 548561, C07D21302, A61K 3144

Patent

active

057191697

ABSTRACT:
The invention relates to benzoylguanidines of the formula I: ##STR1## to pharmaceutically acceptable salts of these compounds and to a process for preparing compounds of the formula I, which comprise reacting a compound of the formula II ##STR2## with guanidine. The compounds of the invention are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5292755 (1994-03-01), Englert et al.
Derwent Abstract of WO 93/04048, 1993.
A. Schomig et al., "Inhibition of Na.sup.+ /H.sup.+ exchange suppresses noradrenaline release and arrhythmias in the ischemic rat heart, " Eur. Heart J. 9(suppl. 1): 167 (1988), Book of abstracts.

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