Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-07-20
1994-11-08
Chang, Celia
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544317, 544326, 544327, 546143, 546159, 546309, 548152, 548178, 562512, 564 52, 564192, 564440, C07D21302, C07D23924, C07C32333, C07C27518
Patent
active
053628780
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.21 and R.sup.22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula ##STR2## and the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
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Kirk-Othmer "Concise Encyclopedia of Chemical Technology" Wiley Interscience Publish, pp. 989-999 (1990).
Bennett "Concise Chemical and Technical Dictionary" Chemical Publishing, p. 885 (1976).
Kepler "Preparation of C.sup.14 and T-labeled compounds" CA:106:67055x (1987).
Chang George
Hamanaka Ernest S.
McCarthy Peter A.
Truong Thien
Walker Frederick J.
Bekelnitzky Seymour G.
Chang Celia
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
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