Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-12-27
1998-12-08
Huff, Sheela
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, 435 691, 435 693, 435 711, 4353201, 435273, 4352573, 530350, C07H 2102, C07H 2104
Patent
active
058470930
ABSTRACT:
The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
REFERENCES:
Kerr, J.F. et al., "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics." Br.J.Cancer (1972) 26 (4):239-257.
Steller, H., "Mechanisms and Genes of Cellular Suicide", Science (1995) 267:1445-1450.
Thompson, C.B., "Apoptosis in the Pathogenesis and Treatment of Disease", Science (1995) 267:1456-1461.
Boyd, J.M. et al., "Adenovirus E1B 19 kDa and Bcl-2 Proteins Interact with a Common Set of Cellular Proteins", Cell (1994) 79:341-351.
Farrow, S.N. et al., "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.", Nature (1995) 374:731-739.
Sentman, C.L. et al., "bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.", Cell (1991) 67:879-888.
Stanger, B.Z. et al., "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.", Cell (1995) 81 (4):513-523.
Bandman Olga
Goli Surya K.
Hillman Jennifer L.
Billings Lucy J.
Huff Sheela
Incyte Pharmaceuticals Inc.
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