Synthesis of polyketides from diketides

Details Synthesis of polyketides from diketides Synthesis of polyketides from diketides

1996-07-05

2000-06-27

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435 71, 435 64, C12P 100

Patent

active

060805552

ABSTRACT:
Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.

REFERENCES:
patent: 5824513 (1998-10-01), Katz
Donadio S, et al, (1993) An erythromycin analog produced by reprogramming of polyketide synthesis. Proc.Natl.Acad.Sci.U.S.A. 90: 7119-7123.
Donadio S, et al, (1992) Biosynthesis of the erythromycin macrolactone and a rational approach for producing hydrid macrolides. Gene 115: 97-103.
Omura, et al., "Inhibition of the Biosynthesis of Leucomycin, a Macrolide Antibiotic, by Cerulenin," J. Biochem. 75: 193-195 (1974).
Rudd, et al., "Genetics of Actinorhodin Biosynthesis by Streptomyces Coelicolor A3(2)," J. Gen. Microbiol. 114:35-43 (1979).

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