Regioselective synthesis of 9-substituted purine acyclonucleosid

Details Regioselective synthesis of 9-substituted purine acyclonucleosid Regioselective synthesis of 9-substituted purine acyclonucleosid

1988-02-02

1989-01-31

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544276, 544277, C07D47318, A61K 3152

Patent

active

048017108

ABSTRACT:
A process for preparing 9-substituted guanine-containing acyclonucleosides comprising selective alkylation at the 9-position of the purine by utilizing a blocking group at the 6-position.

REFERENCES:
patent: 4495190 (1985-01-01), Hagberg et al.
patent: 4579849 (1986-04-01), MacCoss et al.
Ogilvie et al., Can J. Chem., vol. 60, 3005-3010 (1962).
Martin et al., J. Med. Chem. (1983), vol. 26, No. 5, pp. 759-761.
Lee et al., Jour of Org Chemistry, vol. 37, pp. 2923-2927 (1972).

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