Substituted azepino[2,1-a]isoquinoline compounds

Details Substituted azepino[2,1-a]isoquinoline compounds Substituted azepino[2,1-a]isoquinoline compounds

1993-07-26

1994-11-08

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540522, A61K 3155, C07D48714, C07D48716

Patent

active

053627270

ABSTRACT:
Compounds of the formula ##STR1## wherein A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective as ACE inhibitors. Methods of preparation and intermediates are also disclosed.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4337201 (1982-06-01), Petrillo
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4415496 (1983-11-01), Harris et al.
patent: 4432971 (1984-02-01), Karanewsky et al.
patent: 4432972 (1984-02-01), Karanewsky et al.
patent: 4460579 (1984-07-01), Karanewsky et al.
patent: 4584294 (1986-04-01), Ruyle
patent: 4617301 (1986-10-01), Patchett et al.
patent: 4711884 (1987-12-01), Karanewsky
patent: 4722810 (1988-02-01), Delaney et al.
patent: 4749688 (1988-06-01), Haslanger et al.
patent: 4801609 (1989-01-01), Haslanger et al.
patent: 4824832 (1989-04-01), Flynn
patent: 4873235 (1989-10-01), Parsons et al.
patent: 4879309 (1989-11-01), Doll et al.
patent: 5061710 (1991-10-01), Haslanger et al.
patent: 5075302 (1991-12-01), Neustadt
patent: 5098934 (1992-03-01), Vevert et al.
patent: 5190974 (1993-03-01), Clemence et al.
patent: 5208236 (1993-05-01), Neustadt
patent: 5232920 (1993-08-01), Neustadt
Smith et al., Biochemistry, vol. 14, pp. 766-771 (1975).
Thorsett, Actual Chim. Ther., vol. 13, pp. 257-268 (1986).

Affiliated with

Also associated with

Rating

Substituted azepino[2,1-a]isoquinoline compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted azepino[2,1-a]isoquinoline compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted azepino[2,1-a]isoquinoline compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1782624