Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-06
1998-12-08
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514913, A61K 31415
Patent
active
058469923
ABSTRACT:
Herein is described an ocular composition comprising an ocular decongestant such as phenylephrine and certain labdane derivatives which are intraocular pressure lowering agents. The composition not only markedly reduces the ocular reddening otherwise produced by such labdane compounds, but also unexpectedly prolongs and frequently potentiates their intraocular pressure lowering effect. Both of these effects are very beneficial to the use of such labdanes for the treatment of glaucoma.
Also described herein is an ocular composition comprising para-aminoclonidine (an .alpha..sub.2 -adrenoreceptor agonist) and certain labdane derivatives mentioned above. The composition reduces the ocular reddening and lacrimation, and also potentiates the intraocular pressure lowering effect.
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Conway Paul Gary
Helsley Grover Cleveland
Roehr Joachim Eggert
Collier Kenneth J.
Fay Zohreh
Hoechst Marion Roussel Inc.
Ikeda Tatsuya
Simmons Edlyn S.
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