2-alkenylene-thieno-1,2-thiazole derivatives with lipid-lowering

Details 2-alkenylene-thieno-1,2-thiazole derivatives with lipid-lowering 2-alkenylene-thieno-1,2-thiazole derivatives with lipid-lowering

1986-06-19

1989-01-31

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548209, 548210, C07D51304, A61K 31425

Patent

active

048015911

ABSTRACT:
The invention relates to new thieno-1,2-thiazole derivatives of the formula ##STR1## wherein A, with the two carbon atoms of the thiazole ring, forms a group of the formula ##STR2## and the broken line indicates the double bond present in the thieno structures of the formulae IIa and IIb, n denotes the integer 2, 3 or 4, R denotes hydrogen or lower alkyl, R.sub.1 denotes hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy or lower alkylthio and R.sub.2 denotes hydrogen, lower alkyl or halogen; and the pharmaceutically acceptable salts of compounds of the formula I wherein R denotes hydrogen, a process for their preparation, pharmaceutical products containing these compounds, and their use in medicaments. The compounds of the formula I and salts thereof have a lipid-lowering action.

REFERENCES:
patent: 2957883 (1960-10-01), Novello
patent: 4563474 (1986-01-01), Franke et al.
Abstract for Japan Patent #48-24735 (7/24/73).
Abstract for Japan Patent #49-20779 (5/27/74).
Abstract for Japan Patent #53-32118 (3/27/78).
Organic Chemistry, by Morrison and Boyd, (Allyn & Bacon Publ.), (2nd ed.), pp. 582-583 (1966).
Modern Synthetic Reactions by House, (W. A. Benjamin, Publ.), pp. 170-171 (1965).
"Biotransformation von Arzneimitteln" by Pfeifer et al., vol. 5, p. 442 and vol. 4, p. 146 (1981).

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