Oxopyridazinylthiomethyl derivatives of ureidocephalosporins

Details Oxopyridazinylthiomethyl derivatives of ureidocephalosporins Oxopyridazinylthiomethyl derivatives of ureidocephalosporins

1976-08-16

1977-10-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 21, 544 27, 424246, C07D50136, A61K 31545

Patent

active

040525546

ABSTRACT:
Ureido cephalosporin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl or phenyl-lower alkyl, or certain heterocyclic groups; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or methoxy; R.sub.4 is hydrogen, halogen, lower alkyl, or lower alkoxy; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl, phenyl, or phenyl-lower alkyl; are disclosed. These compounds are useful as anti-bacterial agents.

REFERENCES:
patent: 3860591 (1975-01-01), Breuer
patent: 3892737 (1975-07-01), Ochiai et al.
patent: 3978051 (1976-08-01), Dolfini

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