Preparation of 4-fluoro-3-phenoxy-toluene

Details Preparation of 4-fluoro-3-phenoxy-toluene Preparation of 4-fluoro-3-phenoxy-toluene

1980-07-18

1982-02-23

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 4101

Patent

active

043169945

ABSTRACT:
A process for the preparation of 4-fluoro-3-phenoxytoluene of the formula ##STR1## comprising reacting 3-bromo-4-fluoro-toluene of the formula ##STR2## with an alkali metal or alkaline earth metal phenolate in the presence of copper as catalyst and in the presence if isoquinoline as diluent at a temperature between about 100.degree. and 200.degree. C. Advantageously the reaction is effected in the presence of about 0.9 to 1.5 mols of potassium or magnesium carbonate, about 1 to 1.2 mols of the phenolate, about 1 to 50 g of copper, copper(I) oxide, copper(I) chloride or copper (I) bromide as catalyst and about 150 to 1,500 ml of isoquinoline per mol of 3-bromo-4-fluoro-toluene.

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