Ring closure of N-phthaloylglutamines

Details Ring closure of N-phthaloylglutamines Ring closure of N-phthaloylglutamines

1993-10-20

1995-10-31

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

528331, 528317, C07D40104

Patent

active

054630630

ABSTRACT:
Cyclic imides are inhibitors of tumor necrosis factor .alpha. and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-(2,6-dioxo-3-piperidinyl)-4-azaisoindoline-1,3-dione.

REFERENCES:
Fieser, Louis F., Experiments in Organic Chemistry, 3rd edition, p. 75, 1955.
J. C. Craig, "Absolute Configuration . . . ", J Org Chem, vol. 53, pp. 1167-1170, 1988.

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