Modified ciliary neurotrophic factors

Details Modified ciliary neurotrophic factors Modified ciliary neurotrophic factors

1994-09-19

1998-12-08

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 930120, A61K 3818, C07K 1448

Patent

active

058469354

ABSTRACT:
Modified ciliary neurotrophic factors and methods for their production and therapeutic use. Also described is a method of screening for novel therapeutic proteins by determining altered electrophoretic binding properties.

REFERENCES:
patent: 4959314 (1990-09-01), Mark et al.
patent: 4997929 (1991-03-01), Collins et al.
patent: 5593857 (1997-01-01), Higaki
Panayotatos et al. J. Biol. Chem. 268(1993): 19000-19003.
Cunningham et al. Science 244(1989): 1081-1085.
Masiakowski, et al., Recombinant Human and Rat Ciliary Neurotrophic Factors, J. Neurochemistry 57:1003-1012 (1991).
Lin, et al., Purification, Cloning and Expression of Ciliary Neurotrophic Factor, Science 246: 1023-1025 (1989).
Alber, T., Mutational Effects on Protein Stability, Annu. Rev. Biochem. 58: 765-798 (1989).

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