Isolated nucleic acid molecules which encode MAGE derived nonape

Details Isolated nucleic acid molecules which encode MAGE derived nonape Isolated nucleic acid molecules which encode MAGE derived nonape

1993-06-07

1995-10-31

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 536 231, 536 235, C12N 1512, C12N 121, C12N 510

Patent

active

054628717

ABSTRACT:
The invention relates to isolated nucleic acid molecules which encode nonapeptides derived from MAGE tumor rejection antigen precursors. The nonapeptides form complexes with human leukocyte antigens presented on the surfaces of cells, and lead to lysis of these cells by cytolytic T lymphocytes. Thus, they are useful in diagnostic methods. Also a part of the invention are vectors which are designed to encode the nonapeptides as well as cell lines which have been transformed or transfected with the isolated nucleic acid molecules of the invention, or vectors including these molecules.

REFERENCES:
patent: 5262177 (1993-11-01), Brown et al.
patent: 5342774 (1994-08-01), Boon et al.

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