Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap

Details Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap

1984-11-09

1986-05-13

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

260366, 549417, C07F 1500

Patent

active

045888310

ABSTRACT:
The invention relates to platinum complexes of the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 represent alkyl radicals with 1 to 18 carbon atoms, or R.sub.1 or R.sub.2 represent a hydrogen atom and R.sub.2 or R.sub.1 can represent an alkyl radical or a ##STR2## in which R.sub.3 is a hydrogen atom or the ##STR3## radical or an acyl radical, and x=1 or 2. These compounds can be produced by reaction of an alcohol solution of a 5,8-dihydroxyl-1,4-naphthoquinone of the following formula: ##STR4## in which the substituents R.sub.1 and R.sub.2 have the aforementioned meanings, in the presence of a concentrated aqueous ammonia solution, which adjusts the pH over 7, with K.sub.2 PtCl.sub.4 at room temperature. These platinum complex compounds are characterized by a good antitumor effect with low toxicity.

REFERENCES:
patent: 3892790 (1975-07-01), Tobe et al.
patent: 3904663 (1975-09-01), Tobe et al.
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4200583 (1980-04-01), Kidani et al.
patent: 4283342 (1981-08-01), Yolles
Chemical Abstracts 94 157066q (1981).
Chemical Abstracts 94 157067r (1981).
Rosenberg, Naturwissenschaften 1973, 399-406.
Yolles et al., ACS-Symposium 1982, 233-241.
Chem. Abstracts, 1982, 97:48587b.
Chem. Abstracts, 1981, 95:61832f.
Chem. Abstracts, 1980, 93:7882t.
Chem. Abstracts, 1978, 88:15897p and 88:44863e.

Affiliated with

Also associated with

Rating

Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-nap will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1771126