High titer pseudomonas immune serum globulin

Drug – bio-affecting and body treating compositions – Lymphokine

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424 858, 514387, A61K 3940

Patent

active

048014508

ABSTRACT:
Normal plasma from donors who have not been vaccinated with a P seudomonas vaccine or had a Pseudomonas infection can be screened for higher than normal titers of naturally occurring antibody to four or, preferably, two of seven Fisher Immunotypes of Pseudomonas. Those plasmas with higher titers of such antibody can be pooled and fractionated to give hyperimmune serum globulin having high titers of antibody against all seven Fisher Immunotypes. The product may be treated to render it intravenously injectable and the so-prepared material is effective in treating patients with Pseudomonas infection. Also disclosed is a novel antibody preparation including minimum titers of the seven Fisher Immunotypes.

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patent: 4027010 (1975-04-01), Kiseler et al.
patent: 4120950 (1978-10-01), Homna
patent: 4285936 (1981-08-01), Peer et al.
patent: 4482483 (1984-11-01), Curry et al.

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