2-Decarboxy-2-amino-methyl-9-deoxy-9-methylene-PGF-type compound

Details 2-Decarboxy-2-amino-methyl-9-deoxy-9-methylene-PGF-type compound 2-Decarboxy-2-amino-methyl-9-deoxy-9-methylene-PGF-type compound

1977-09-12

1978-10-10

Higel, Floyd D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605705CA, 424325, 424330, C07C 8745, C07C 8750, C07C17700

Patent

active

041196660

ABSTRACT:
This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 691157 (1902-01-01), Merling
patent: 2520015 (1950-08-01), Rohrmann
patent: 2736746 (1956-02-01), Goldberg et al.
patent: 2805266 (1957-09-01), Ziegler et al.
patent: 3046280 (1962-07-01), Kralt et al.
patent: 3920643 (1975-11-01), Just et al.
patent: 3931299 (1976-01-01), Strike
patent: 3931323 (1976-01-01), Buchi et al.

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