N-[Mercaptoacyl (amino acid or peptide ) ] compounds and S-lipop

Harvesters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546249, 549 6, 549491, 549497, 549504, C07C32100

Patent

active

055918913

ABSTRACT:
N-[Mercaptoacyl(amino acid or peptide)] compounds and S-lipophilic aliphatic carbonyl derivatives thereof, and pharmaceutical compositions comprising such compounds, as well as the use of these compounds as antihypertensives by the inhibition of neutral endopeptidase and/or peptidyldipeptidase A are disclosed. Methods for preparing the such compounds and derivatives are disclosed also.

REFERENCES:
patent: 3246025 (1966-04-01), Mita et al.
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4248883 (1981-02-01), Sawayama et al.
patent: 4474799 (1984-10-01), Greenberg et al.
patent: 4513009 (1985-04-01), Roques et al.
patent: 4613587 (1986-09-01), Kessler et al.
patent: 4684660 (1987-08-01), Ondetti et al.
patent: 4738803 (1988-04-01), Roques et al.
patent: 4798904 (1989-01-01), Delaney et al.
patent: 4879309 (1989-11-01), Doll et al.
Roques et al., "The enkephalinase inhibitor thiorphan shows antinociceptive ctivity in mice", 1980, pp. 1-3, Nature, vol. 288, No. 5788.
Roques et al., "Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan", 1983, Proc. Natl. Acad. Sci. vol. 80, pp. 3178-3182.
Roques et al., "Neutral endopeptidase-24. 11 ingibitors: from analgesics to antihypertensives?", Trends in Pharmacological Sciences, vol. 11, No. 6, 1990, pp. 245-249.
Fournie-Zaluski et al., "New Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme. . . ", J. Med. Chem. 37, pp. 1070-1083, 1994.
J. G. C. Van Amsterdam et al., European Journal of Pharmacology, vol. 135, pp. 411-418 (1987).
T. Komori et al., Chemical and Pharmaceutical Bulletin, vol. 35(6), pp. 2388-2393 (1987).
F. Noble et al., Journal of Pharmacol. Exp. Ther., vol. 261(1), pp. 181-190 (1992).
B. P. Roques et al., Nature, vol. 288, pp. 286-288 (1980).
J. A. Koehn et al., J. Biol. Chem., vol. 262, pp. 11623-11627 (1987).
S. L. Stephenson et al., Biochem. J., vol. 243, pp. 183-187 (1987).
G. M. Olins et al., Mol. Cell. Endocrinol., vol. 61, pp. 201-208 (1989).
A. A. Seymour et al., Hypertension, vol. 14(1), pp. 87-97 (1989).
A. M. Richards et al., J. Clin. Endocrinol. Metab., vol. 72(6), pp. 1317-1322 (1991).
A. M. Richards et al., Circulation Res., vol. 71(6), pp. 1501-1507 (1992).
E. P. Kromer et al., Am. J. Hypertens., vol. 4(5), pp. 460-463 (1991).
D. B. Northridge et al., Am. J. Hypertens., vol. 3(9), pp. 682-687 (1990).
B. P. Roques et al., Trends in Pharmacological Sciences, vol. 11, pp. 245-249 (1989).
C. Llorens et al., Biochem. Biophys. Res. Commun., vol. 96, pp. 1710-1716 (1980).
C. Landriscina et al., Biochem. Biophys. Acta, vol. 205, pp. 136-142 (1970).
A. J. Trapani et al., J. Cardiovasc. Pharmacol., vol. 14, pp. 419-424 (1989).
G. Waksman et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 1523-1527 (1986).
B. P. Roques et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 3178-3182 (1983).
G. Hilgetag et al., "Preparative Organic Chemistry", pp. 242-251 and 642, J. Wiley & Sons (1972).
Burnier et al., Clin. Pharmacol. Ther., 1991, 50, 181-191.
Richards et al., J. Cardiovasc. Pharmacol., 1992, 20, 735-741.
Pham et al., J. Pharmacol. Exp. Ther. 1993, 265(3), 1339.
Trippodo et al., J. Pharmacol. Exp. Ther., 1995, 272, 619-627.
Seymour et al., J. Pharmacol. Exp. Ther., 1993, 266(2) 872.
French et al., J. Cardiovac. Pharmacol., 1995, 26, 107-113.
Seymour et al., J. Cardiovasc. Pharmacol., 1991, 17-456-465.
Soubrier et al., Proc. Natl. Acad. Sci., 1988, 85, 9386-9390.
O'Connell et al. Clin. Sci., 1993, 85, 19-26.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

N-[Mercaptoacyl (amino acid or peptide ) ] compounds and S-lipop does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-[Mercaptoacyl (amino acid or peptide ) ] compounds and S-lipop, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-[Mercaptoacyl (amino acid or peptide ) ] compounds and S-lipop will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1765763

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.