Products of a microbiological process for the production of 2-ha

Details Products of a microbiological process for the production of 2-ha Products of a microbiological process for the production of 2-ha

1994-11-23

1997-01-07

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544318, C07D23930, C07D23926, C07D23934

Patent

active

055918530

ABSTRACT:
A 2-halo-pyrimidine-4-carboxylic acid of formula: ##STR1## wherein X is a halogen atom, for example, 2-chloro-pyrimidine-4-carboxylic acid. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula: ##STR2## wherein R.sub.1 is a halogen atom, NH.sub.2 --, HO-- or a C.sub.1 -C.sub.4 alkoxy group and R.sub.2 is a C.sub.1 -C.sub.4 alkoxy group or a halogen atom with the proviso that, if R.sub.1 is a HO-- group, R.sub.2 is not a halogen atom and with the proviso that, if R.sub.2 is a halo group, R.sub.1 is not an amino group. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula III wherein R.sub.1 is a HO-- group and R.sub.2 is an ethoxy group.

REFERENCES:
patent: 5104798 (1992-04-01), Kiener
patent: 5164397 (1992-11-01), George et al.
patent: 5213973 (1993-05-01), Hoeks
Mamaev et al., Chemical Abstracts, vol. 70, entry 76976 (1968).
Shein et al., Chemical Abstracts, vol. 79, entry 17707 (1972).
George et al., Chemical Abstracts, vol. 115, entry 208015 (1990).
George et al., Chemical Abstracts, vol. 117, entry 48597 (1992).
Chemical Abstracts, vol. 94, No. 1, (Jan. 5, 1981) 3979c.
Kulla et al., Arch. Microbiol., 135, (1983), pp. 1 to 7.
Claus & Walker, J. Gen. Microbiol., 36, (1964), pp. 107-122.

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